Professor, Department of Physical and Colloid Chemistry
Kazan Scientific Center of the Russian Academy of Sciences

Dr.Sc. in Chemistry

phone:+7-843-2318936; +7-843-2927347
e-mail: yufzuev@mail.ru

EDUCATION

1973 M.Sc.in radio-physics and electronics, School of Physics, Kazan State University, Kazan, Russia

1985 Ph.D.in Molecular Physics, Kazan State University, Kazan, Russian Federation

2006 Dr.Sc. in Chemistry, Kazan State University, Kazan, Russian Federation

2009 Professor in Chemical Physics, Russian Federation

PROFESSIONAL EXPERIENCE

1973-1974 Technician, Kazan Institute of Biology of USSR Academy of Sciences, Kazan, Russia

1974-1978 Senior Engineer; Kazan Institute of Biology of USSR Academy of Sciences, Kazan, Russia

1978-1988 Research Fellow, Kazan Institute of Biology of USSR Academy of Sciences, Kazan, Russia

1988-2002 Senior Research Fellow, Kazan Institute of Biology of USSR Academy of Sciences, Kazan, Russia (renamed as Kazan Institute of Biochemistry and Biophysics of Russian Academy of Sciences (KIBB RAS) in 1995)

2002-2005 Principal Research Fellow, KIBB RAS

2006-present Head of Laboratory (Biophysical Chemistry of Nanosystems), KIBB RAS

2011-present Institute Vice-Director (KIBB RAS)

2007-present Professor, Chair of Physical and Colloid Chemistry, Kazan State Technological University, Kazan

2016-present Professor, Chair of Water Bioresources and Aquaculture, Kazan State Power Engineering University

2003, 2004, 2006, 2007, 2008, 2009, 2011 Visiting researcher, INRA, Nantes, France – Structural studies of milk proteins

MAIN ACHIEVEMENTS

Winner of the Tatarstan Republic State Prize in Sience and Technology, 2017

Honored Scientific Worker of Tatarstan Republic, 2010

Author and co-author of 300 scientific articles (143 cited by Scopus), 7 book chapters, 11 textbooks and manual textbooks, 3 patents.

RESEARCH INTERESTS

• Physical methods for biological structures

• Dynamical structure of micro-heterogeneous synthetic and natural surfactant-based systems (micellar solutions and microemulsions)

• Chemical reactions (including enzymatic) in micro-heterogeneous surfactant-based systems

• Intermolecular interactions and intramolecular dynamics as regulatory factors of protein functional activity

• Protein engineering, structure and colloid properties

• Biopolymer-ligand complexes: interconnection of structure and biological functioning

• Engineering of DNA-amphiphile lipoplexes for medical applications

PROFESSIONAL SERVICES

• Reviewer of Russian Scientific Foundation (Moscow)

• Reviewer of Russian Foundation for Fundamental Research

• Vice-Chair of the specialized board on Dr. Sc.-degree D 022.004.03 (Biology) in 03.01.02 -Biophysics, 03.01.05 - Plant Biochemistry and Physiology in Federal Research Centre Kazan Scientific Center of RASof Russian Academy of Sciences

• Member of the specialized board on Dr. Sc.-degree D 002.191.01 (Physics and Mathematics) in 01.04.11 - Physics of Magnetic Phenomena, 01.04.17 – Chemical Physics i/n Kazan E. K. Zavoisky Physical-Technical Institute of Russian Academy of Science

• Member of the specialized board on Dr. Sc.-degree D 999.097.02 (Chemistry; Technical Sciences) in 03.02.08 – Ecology (Chemical degree; Technical degree), 03.01.06 – Biotechnology (Technical degree) in Kazan National Research Technological University

MAIN PUBLICATIONS

1999-2001 RFBR, "Influence of the microemulsion dynamic structure on the catalysis of reactions of the phosphoryl and acyl groups transfer"

2002-2004 RFBR, "Interconnection of the water-in-oil microemulsions dynamic structure and functional stability of enzymes solubilyzed in this medium”

2005-2007 RFBR, "Local microenvironment, structural and functional stability of proteins in the surfactant-based microdispersed media"

2005-2007 RAS Presidium Programme “Biomolecular and Medical Chemistry”, Division of Chemistry and Material Science of RAS. “Modeling of enzymes natural microenvironment by supramolecular surfactant-based systems”

2008-2012 RAS Presidium Programme “Molecular and Cellular Biology”, Division of Biological Sciences of RAS. “Microenvironment as regulatory factor of protein structural and dynamic properties and protein-ligand interactions

2009-2011 RFBR, Structure and catalytic effects in supramolecular systems based on Gemini surfactants and enzymes

2010-2012 Federal Aimed Programme, Ministry of Education and Science, “Molecular mechanisms of phytoimmunity: signaling mediators and re programming of gene expression

2012-2014 RFBR, Interaction of amphiphiles with DNA: structure and properties of supramolecule systems for biology and medicine

2013-2014 RFBR-region, Structural and physic-chemical patterns of molecular design of amphiphile-based delivery systems of gene material

2015-2017 RFBR-region, The influence of lipid composition and morphology in formation, structure and properties of fibrin clots

2015-2017 RFBR, Supramolecular chemistry of peptide-based and DNA-based lipoplexes with synthetic amphiphile ligands

2018-2020 RFBR, Composite polysaccharide-protrin hydrogels: moleculat engineering for grug delivery and regenerative medicine

MAIN PUBLICATIONS

1. L.Ya. Zakharova, G.I. Kaupova, D.R. Gabdrakhmanov, G.A. Gaynanova, E.A. Ermakova, A.R. Mukhitov, I.V. Galkina, S.V. Cheresiz, A.G. Pokrovsky, P.V. Skvortsova, Yu.V. Gogolev, Yu.F. Zuev // Alkyl triphenyl phosphonium surfactants as nucleic acid carriers: complexation efficacy toward DNA decamer, interaction with lipid bilayer and cytotoxicity study // Physical Chemistry Chemical Physics, 2019, V. 21, 16706 - 16717. DOI: 10.1039/c9cp02384d. Q1.
2. I. Lunev, A. Greenbaum (Gutina)⁠, Yu. Feldman, V. Petrov, N. Kuznetsova, N. Averianova, O. Makshakova, Yu. Zuev // Dielectric response of hydrated water as a structural component of nanofibrillated cellulose (NFC) from different plant sources // Carbohydrate Polymers, 2019, V. 225, Article 115217. https://doi.org/10.1016/j.carbpol.2019.115217. Q1.
3. Kusova A., Sitnitsky A., Faizullin D., Zuev Yu. Protein Translational Diffusion and Intermolecular Interactions of Globular and Intrinsically Unstructured Proteins // The Journal of Physical Chemistry. Part A. 2019, V. 123, N. 46, P. 10190-10196. DOI: 10.1021/acs.jpca.9b08601. Q1.
4. Makshakova O.N., Faizullin D.A., Zuev Yu.F. // Interplay between secondary structure and ion binding upon thermoreversible gelation of κ-carrageenan // Carbohydrate Polymers, 2020, V. 227, Article 115342. https://doi.org/10.1016/j.carbpol.2019.115342. Q1.
5. D. Faizullin, Yu. Valiullina, V. Salnikov, Yu. Zuev // Direct interaction of fibrinogen with lipid microparticles modulates clotting kinetics and clot structure // Nanomedicine: Nanotechnology, Biology, and Medicine, 2020, V.23 Art. 102098. https://doi.org/10.1016/j.nano.2019.102098. Q1.
6. O.S. Zueva, A.M. Kusova, A.O. Makarova, A.Turanov, A.Iskhakova, V.V. Salnikov, Yu.F. Zuev // Reciprocal Effects of Multi-Walled Carbon Nanotubes and Oppositely Charged Surfactants in Bulk Water and at Interfaces // Colloids and Surfaces A 603 (2020) 125296. https://doi.org/10.1016/j.colsurfa.2020.125296. Q1.
7. Makshakova O.N., Safarova E.R., Zuev Y.F. // Structural insights in interactions between RNase from Bacillus Intermedius and rhamnogalacturonan I from potato // Carbohydrate Polymers, 2021, V.251. N 117038. https://doi.org/10.1016/j.carbpol.2020.117038. Q1.
8. A.M. Kusova, A.E. Sitnitsky and Y.F. Zuev // Impact of intermolecular attraction and repulsion on molecular diffusion and virial coefficients of spheroidal and rod-shaped proteins, Journal of Molecular Liquids, 2021, V. 323, N 114927. https://doi.org/10.1016/j.molliq.2020.114927. Q1.
9. O.N. Makshakova, D.A. Faizullin, P.V. Mikshina, T.A. Gorshkova, Yu. F. Zuev // Spatial Structures of Rhamnogalacturonan I in Gel and Colloidal Solution Identified by 1D and 2D-FTIR Spectroscopy // Carbohydrate Polymers 2018. V. 192. P. 231-239. https://doi.org/10.1016/j.carbpol.2018.03.059.
10. Yu. F. Zuev, R. I. Litvinov, A. E. Sitnitsky, B. Z. Idiyatullin, D. R. Bakirova, D. Galanakis, A. Zhmurov, V. Barsegov, J. W. Weisel // Conformational Flexibility and Self-Association of Fibrinogen in Concentrated Solutions // J. Physical Chemistry B, 2017, V. 121, N 33, P. 7833–7843. DOI: 10.1021/acs.jpcb.7b05654.
11. D.A. Faizullin, T.A. Konnova, T. Haertle, Yu.F. Zuev // Secondary structure and colloidal stability of beta-casein in microheterogeneous water-ethanol solutions // Food Hydrocolloids 2017, V. 63, P. 349-355. Doi: 10.1016/j.foodhyd.2016.09.011.
12. L.Ya. Zakharova, D.R. Gabdrakhmanov, A.R. Ibragimova, E.A. Vasilieva, I.R. Nizameev, M.K. Kadirov, E.A. Ermakova, N.E. Gogoleva, D.A. Faizullin, A.G. Pokrovsky,V.A. Korobeynikov, S.V. Cheresiz, Yu.F. Zuev // Structural, biocomplexation and gene delivery properties of hydroxyethylated gemini surfactants with varied spacer length // Colloids and Surfaces B: Biointerfaces. 2016. V.140. P. 269–277.
13. А.Т. Губайдуллин, И.А. Литвинов, А.И. Самигуллина, О.С. Зуева, В.С. Рухлов, Б.З. Идиятуллин, Ю.Ф. Зуев // Структура и динамика концентрированных мицеллярных растворов додецилсульфата натрия // Известия Академии наук. Серия химическая, 2016, № 1, С.158-166.
14. E.A. Ermakova, D.A. Faizullin, B.Z. Idiyatullin, B.I. Khairutdinov, L.N. Mukhamedova, N.B. Tarasova, Ya.Y. Toporkova, E.V. Osipova, V. Kovaleva, Yu.V. Gogolev, Yu.F. Zuev, I.V. Nesmelova // Structure of Scots pine defensin 1 by spectroscopic methods and computational modeling // Int. J. Biological Macromolecules. 2016. V. 84. P.142–152.
15. O.N. Makshakova, P.I. Semenyuk, M.L. Kuravsky, E.A. Ermakova, Yu.F. Zuev, V.I. Muronetz // Structural basis for regulation of stability and activity in glyceraldehyde-3-phosphate dehydrogenases. Differential scanning calorimetry and molecular dynamics // Journal of Structural Biology, 2015, V. 190, N2, С. 224-235.
16. L.D. Zubairova, R.M. Nabiullina, C. Nagaswami, Yu.F. Zuev, I.G. Mustafin, R.I. Litvinov, J.W. Weisel // Circulating microparticles alter formation, structure, and properties of fibrin clots // Scientific Reports. 2015. V.5. 17611. DOI: 10.1038/srep17611.
17. L.Ya. Zakharova, E.A. Vasilieva, G.A. Gaynanova, A.B. Mirgorodskaya, A.R. Ibragimova, V.V. Salnikov, I.F. Uchegbu, A.I. Konovalov, Yu.F. Zuev // The polyacrylic acid/modified chitosan capsules with tunable release of small hydrophobic probe and drug // Colloids and Surfaces A: Physicochem. Eng. Aspects. 2015. V. 471. P. 93–100.
18. P.V. Mikshina, B.Z. Idiyatullin, A.A. Petrova, A.S. Shashkov, Y.F. Zuev, T.A. Gorshkova // Spatial organization of complex rhamnogalacturonan I from gelatinous fibers - “muscles” of plant organism // Carbohydrate Polymers. 2015. V. 117, P. 853-861.
19. G. Leighton, T. Konnova, B. Idiyatullin, S. Hurr, Yu.F. Zuev, I.V. Nesmelova // The folding of the specific DNA recognition subdomain of the Sleeping Beauty transposase is temperature-dependent and is required for its binding to the transposon DNA // PLoS ONE, V. 9, Is. 11, 6 November 2014, Article number e112114.
20. B. Khairutdinov, E. Ermakova, A. Sitnitsky, I. Stoikov, Yu. Zuev // Supramolecular complex formed by DNA oligonucleotide and thiacalix4]arene. NMR-spectroscopy and molecular docking // Journal of Molecular Structure, 2014, V.1074, P. 126-133.

LANGUAGE PROFICIENCY

Russian: native
English: fluent